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SNRIs and Tricyclics

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Aug. 10th, 2012 | 11:30 pm
posted by: lorcas_novena in crazy_academics

Hi guys, 

I was just wondering if you knew whether it was possible to combine a SNRI (Venlafaxine) with a tricyclic? My doctor doesn't want me to come off the Effexor and I don't want to be seen an being non-compliant, but I know tricyclics work better for my anxiety. wondering if I can suggest supplementing it with Lofepramine or something. 


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Comments {3}


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from: nulz
date: Aug. 10th, 2012 11:21 pm (UTC)

i think it's possible, yes. you might be prescribed a lower dose of the tricyclic instead of the standard dose but that would depend on your doctor's opinion!

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from: lorcas_novena
date: Aug. 11th, 2012 09:01 am (UTC)

Thanks :)

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from: smokeline
date: Sep. 12th, 2012 04:26 am (UTC)

I would actually think that's not a good idea. Both types of drug act to increase serotonin, and taking two such drugs together can trigger serotonin syndrome. It's pretty dangerous. Unless your doctor is specifically prescribing them together at appropriate low doses, I wouldn't risk it.

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